| Pair Name | Fisetin, Paclitaxel | ||
| Phytochemical Name | Fisetin (PubChem CID: 5281614 ) | ||
| Anticancer drug Name | Paclitaxel (PubChem CID: 36314 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Fisetin, Paclitaxel | |||
| Disease Info | [ICD-11: 2C73] | Ovarian cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | ABCG2 | hsa9429 |
| Up-regulation | Expression | BAK1 | hsa578 | |
| Down-regulation | Expression | BCL-xL | hsa598 | |
| Up-regulation | Activity | CASP3 | hsa836 | |
| In Vitro Model | OVCAR-3 | High grade ovarian serous adenocarcinoma | Homo sapiens (Human) | CVCL_0465 |
| Caov-3 | High grade ovarian serous adenocarcinoma | Homo sapiens (Human) | CVCL_0201 | |
| TOV-112D | Ovarian endometrioid adenocarcinoma | Homo sapiens (Human) | CVCL_3612 | |
| SW626 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_1725 | |
| Result | Our study shows that PTX-FA and Fis-FA PBM NPs directly target platinum-resistant OvCa cells, induce cytotoxic/apoptotic effects, and reverse multi-drug resistance (MDR). These findings allow us to create new clinical applications using PTX-FA and Fis-FA combination nanoparticles to treat drug-resistant cancers. | |||
| No. | Title | Href |
|---|---|---|
| 1 | The effect of paclitaxel- and fisetin-loaded PBM nanoparticles on apoptosis and reversal of drug resistance gene ABCG2 in ovarian cancer. J Ovarian Res. 2023 Nov 21;16(1):220. doi: 10.1186/s13048-023-01308-w. | Click |
